How Cigarette Smoking Causes Cancer

  • Cigarette smoking is the most important risk factor for NSCLC
  • It contains more than 300 chemicals, 40 of which are known to be potent carcinogens (cancer causing agents)
  • The N-nitrosamine and polycyclic aromatic hydrocarbons (PAH) are the two main classes of tobacco-related inhaled carcinogens
  • Changes in the composition and makeup of cigarettes have resulted in low-tar low- yield filter cigarettes. As a result smokers compensate by smoking more cigarettes, puffing more vigorously, and inhaling deeper
  • The risk of lung cancer is related to the duration as well as intensity of smoking
  • Lung cancer risk in smokers can be significantly diminished in a time-dependent manner following smoking cessation
  • Environmental tobacco smoke (ETS) exposure (passive smoking) contributes to 25% of all lung cancers in nonsmokers